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Death in infancy

MedGen UID:
348942
•Concept ID:
C1858430
•
Finding
Synonyms: Death in early childhood; Infantile death; Lethal in infancy
 
HPO: HP:0001522

Definition

Death within the first 24 months of life. [from HPO]

Professional guidelines

PubMed

Ethical issues with testing and treatment for Krabbe disease.
Ehmann P, Lantos JD
Dev Med Child Neurol 2019 Dec;61(12):1358-1361. Epub 2019 May 15 doi: 10.1111/dmcn.14258. PMID: 31090922
Childhood psychosocial development and fatal injuries in Gauteng, South Africa.
Pretorius K, Van Niekerk A
Child Care Health Dev 2015 Jan;41(1):35-44. Epub 2014 Apr 15 doi: 10.1111/cch.12140. PMID: 24734788
EXOSC3 mutations in pontocerebellar hypoplasia type 1: novel mutations and genotype-phenotype correlations.
Eggens VR, Barth PG, Niermeijer JM, Berg JN, Darin N, Dixit A, Fluss J, Foulds N, Fowler D, Hortobágyi T, Jacques T, King MD, Makrythanasis P, Máté A, Nicoll JA, O'Rourke D, Price S, Williams AN, Wilson L, Suri M, Sztriha L, Dijns-de Wissel MB, van Meegen MT, van Ruissen F, Aronica E, Troost D, Majoie CB, Marquering HA, Poll-Thé BT, Baas F
Orphanet J Rare Dis 2014 Feb 13;9:23. doi: 10.1186/1750-1172-9-23. PMID: 24524299Free PMC Article

Recent clinical studies

Etiology

Procalcitonin is associated with sudden unexpected death in infancy due to infection.
Collette M, Hauet M, de Visme S, Borsa A, Schweitzer C, Marchand E, Martrille L, Wiedemann A
Eur J Pediatr 2023 Sep;182(9):3929-3937. Epub 2023 Jun 23 doi: 10.1007/s00431-023-05064-3. PMID: 37353601
Regional variation in sudden unexpected death in infancy in New Zealand.
Mitchell EA, Taylor BJ, Milne BJ
J Paediatr Child Health 2023 Feb;59(2):319-327. Epub 2022 Dec 13 doi: 10.1111/jpc.16293. PMID: 36511387Free PMC Article
Butyrylcholinesterase is a potential biomarker for Sudden Infant Death Syndrome.
Harrington CT, Hafid NA, Waters KA
EBioMedicine 2022 Jun;80:104041. Epub 2022 May 6 doi: 10.1016/j.ebiom.2022.104041. PMID: 35533499Free PMC Article
Sudden Unexpected Death in Infancy [SUDI]: What the clinician, pathologist, coroner and researchers want to know.
Fitzgerald DA, Jeffery H, Arbuckle S, du Toit-Prinsloo L, O'Sullivan T, Waters K
Paediatr Respir Rev 2022 Mar;41:14-20. Epub 2021 Aug 13 doi: 10.1016/j.prrv.2021.08.002. PMID: 34998675
New Frameworks for Understanding Sudden Unexpected Deaths in Infancy (SUDI) in Socially Vulnerable Families.
Shipstone R, Young J, Kearney L
J Pediatr Nurs 2017 Nov-Dec;37:35-41. Epub 2017 Jul 8 doi: 10.1016/j.pedn.2017.06.022. PMID: 28697921

Diagnosis

Procalcitonin is associated with sudden unexpected death in infancy due to infection.
Collette M, Hauet M, de Visme S, Borsa A, Schweitzer C, Marchand E, Martrille L, Wiedemann A
Eur J Pediatr 2023 Sep;182(9):3929-3937. Epub 2023 Jun 23 doi: 10.1007/s00431-023-05064-3. PMID: 37353601
Butyrylcholinesterase is a potential biomarker for Sudden Infant Death Syndrome.
Harrington CT, Hafid NA, Waters KA
EBioMedicine 2022 Jun;80:104041. Epub 2022 May 6 doi: 10.1016/j.ebiom.2022.104041. PMID: 35533499Free PMC Article
Sudden Unexpected Death in Infancy [SUDI]: What the clinician, pathologist, coroner and researchers want to know.
Fitzgerald DA, Jeffery H, Arbuckle S, du Toit-Prinsloo L, O'Sullivan T, Waters K
Paediatr Respir Rev 2022 Mar;41:14-20. Epub 2021 Aug 13 doi: 10.1016/j.prrv.2021.08.002. PMID: 34998675
Metabolic disease in 10 patients with sudden unexpected death in infancy or acute life-threatening events.
Takahashi T, Yamada K, Kobayashi H, Hasegawa Y, Taketani T, Fukuda S, Yamaguchi S
Pediatr Int 2015 Jun;57(3):348-53. doi: 10.1111/ped.12660. PMID: 25919294
Sudden unexpected death in infancy: a historical perspective.
Mitchell EA, Krous HF
J Paediatr Child Health 2015 Jan;51(1):108-12. doi: 10.1111/jpc.12818. PMID: 25586853

Therapy

Inconsistency Between Pictures on Baby Diaper Packaging in Europe and Safe Infant Sleep Recommendations.
de Visme S, Korevaar DA, Gras-Le Guen C, Flamant A, Bevacqua M, Stanzelova A, Trinh NTH, Ciobanu DA, Carvalho AA, Kyriakoglou I, Fuentes M, Refes Y, Briand-Huchet E, Sellier AL, Harrewijn I, Cohen JF, Chalumeau M
J Pediatr 2024 Jan;264:113763. Epub 2023 Sep 29 doi: 10.1016/j.jpeds.2023.113763. PMID: 37778411
Assessing retinal hemorrhages with non-invasive post-mortem fundus photographs in sudden unexpected death in infancy.
Ducloyer JB, Scherpereel C, Goronflot T, Le Meur G, Lebranchu P, Jossic F, Scolan V, Ducloyer M
Int J Legal Med 2023 May;137(3):913-923. Epub 2023 Feb 23 doi: 10.1007/s00414-023-02964-9. PMID: 36823412Free PMC Article
Feasibility and Acceptability of a Tailored Infant Safe Sleep Coaching Intervention for African American Families.
Salm Ward TC, McPherson J, Kogan SM
Int J Environ Res Public Health 2021 Apr 14;18(8) doi: 10.3390/ijerph18084133. PMID: 33919783Free PMC Article
Sudden deaths in adult-worn baby carriers: 19 cases.
Bergounioux J, Madre C, Crucis-Armengaud A, Briand-Huchet E, Michard-Lenoir AP, Patural H, Dauger S, Renolleau S, Teychéne AM, Henry S, Biarent D, Robin C, Werner E, Rambaud C
Eur J Pediatr 2015 Dec;174(12):1665-70. Epub 2015 Jul 15 doi: 10.1007/s00431-015-2593-6. PMID: 26174105

Prognosis

Infant Care Practices, Caregiver Awareness of Safe Sleep Advice and Barriers to Implementation: A Scoping Review.
Cole R, Young J, Kearney L, Thompson JMD
Int J Environ Res Public Health 2022 Jun 23;19(13) doi: 10.3390/ijerph19137712. PMID: 35805369Free PMC Article
National Variations in Recent Trends of Sudden Unexpected Infant Death Rate in Western Europe.
de Visme S, Chalumeau M, Levieux K, Patural H, Harrewijn I, Briand-Huchet E, Rey G, Morgand C, Blondel B, Gras-Le Guen C, Hanf M
J Pediatr 2020 Nov;226:179-185.e4. Epub 2020 Jun 23 doi: 10.1016/j.jpeds.2020.06.052. PMID: 32585240
Origins of disparities in preventable child mortality in England and Sweden: a birth cohort study.
Zylbersztejn A, Gilbert R, Hjern A, Hardelid P
Arch Dis Child 2020 Jan;105(1):53-61. Epub 2019 Jun 26 doi: 10.1136/archdischild-2018-316693. PMID: 31243008Free PMC Article
Sudden Unexpected Death in Neonates: A Clinico-pathological Study.
Reyes JA, Somers GR, Chiasson DA
Pediatr Dev Pathol 2018 Nov-Dec;21(6):528-536. Epub 2018 Apr 11 doi: 10.1177/1093526618764054. PMID: 29642737
Metabolic disease in 10 patients with sudden unexpected death in infancy or acute life-threatening events.
Takahashi T, Yamada K, Kobayashi H, Hasegawa Y, Taketani T, Fukuda S, Yamaguchi S
Pediatr Int 2015 Jun;57(3):348-53. doi: 10.1111/ped.12660. PMID: 25919294

Clinical prediction guides

Procalcitonin is associated with sudden unexpected death in infancy due to infection.
Collette M, Hauet M, de Visme S, Borsa A, Schweitzer C, Marchand E, Martrille L, Wiedemann A
Eur J Pediatr 2023 Sep;182(9):3929-3937. Epub 2023 Jun 23 doi: 10.1007/s00431-023-05064-3. PMID: 37353601
Background predictors of time to death in infancy: evidence from a survival analysis of the 2018 Nigeria DHS data.
Kunnuji M, Eshiet I, Ahinkorah BO, Omogbemi T, Yaya S
BMC Public Health 2022 Jan 6;22(1):15. doi: 10.1186/s12889-021-12424-x. PMID: 34991534Free PMC Article
Cultural variation in factors associated with sudden infant death during sleep.
Ahn YM, Yang KM, Ha HI, Cho JA
BMC Pediatr 2021 Oct 9;21(1):443. doi: 10.1186/s12887-021-02894-8. PMID: 34627192Free PMC Article
National Variations in Recent Trends of Sudden Unexpected Infant Death Rate in Western Europe.
de Visme S, Chalumeau M, Levieux K, Patural H, Harrewijn I, Briand-Huchet E, Rey G, Morgand C, Blondel B, Gras-Le Guen C, Hanf M
J Pediatr 2020 Nov;226:179-185.e4. Epub 2020 Jun 23 doi: 10.1016/j.jpeds.2020.06.052. PMID: 32585240
Infectious causes of sudden infant death syndrome.
Alfelali M, Khandaker G
Paediatr Respir Rev 2014 Dec;15(4):307-11. Epub 2014 Sep 19 doi: 10.1016/j.prrv.2014.09.004. PMID: 25441371

Recent systematic reviews

Cultural variation in factors associated with sudden infant death during sleep.
Ahn YM, Yang KM, Ha HI, Cho JA
BMC Pediatr 2021 Oct 9;21(1):443. doi: 10.1186/s12887-021-02894-8. PMID: 34627192Free PMC Article
Improving engagement with services to prevent Sudden Unexpected Death in Infancy (SUDI) in families with children at risk of significant harm: A systematic review of evidence.
Garstang J, Watson D, Pease A, Ellis C, Blair PS, Fleming P
Child Care Health Dev 2021 Sep;47(5):713-731. Epub 2021 May 12 doi: 10.1111/cch.12875. PMID: 33929753

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